Chemotherapy and/or Metastasectomy in Treating Patients With Metastatic Colorectal Adenocarcinoma With Lung Metastases

Inclusion Criteria: * Histological confirmation of colorectal adenocarcinoma * Metastatic colorectal cancer involving the lung classified as determined by the treating clinical team * Diagnosis of colorectal metastasis to lung made either histologically with trans-thoracic needle biopsy or clinically based on radiographic imaging * Identification as a medically appropriate candidate for surgical resection of the lung metastasis (metastases) according to the evaluating cardiothoracic surgeon. Standard justification for deeming a patient medically operable based on: * Pulmonary reserve adequate to tolerate complete resection of all intrathoracic disease, as deemed by thoracic surgeon, which may be determined by: * Baseline forced expiratory volume in one second (FEV1) \> 40% predicted * Post-operative predicted FEV1 \> 30% predicted * Diffusion capacity of the lung for carbon monoxide (DLCO) \> 40% predicted * Absent baseline hypoxemia and/or hypercapnia * Exercise oxygen consumption \> 50% predicted * Absent severe pulmonary hypertension * Absent severe cerebral, cardiac, or peripheral vascular disease * Absent severe chronic heart disease * Ability to tolerate surgical resection and acceptable operative risk as deemed by thoracic surgeon based on performance status and medical comorbidities * Identification as a medically appropriate candidate for systemic chemotherapy at the discretion of the evaluating medical oncologist * Resection/de…