CompletedNot Applicable

Respiratory Function of Dexmedetomidine in Patients Undergoing Pleuroscopy

Greece60 participantsStarted 2018-08-05

Plain-language summary

The primary objective of this prospective trial will be to assess the effects of dexmedetomidine administration on oxygenation and respiratory function in patients undergoing diagnostic or therapeutic medical thoracoscopy/pleuroscopy for a pleural effusion compared to conventional conscious sedation/monitored anesthesia care (MAC) with midazolam. The secondary endpoint of the study will be to also assess the effects of dexmedetomidine administration on respiratory mechanics and postprocedural complications

Who can participate

Age range

18 Years – 100 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age ≥ 18 years old * American Society of Anesthesiologists (ASA) physical status of I-IV * scheduled to undergo medical thoracoscopy/pleuroscopy. Exclusion Criteria: * general anesthesia within 7 days prior to study entry * received an α2-agonist or antagonist within 14 days before the procedure * received an intravenous opioid within 1 hour * received an oral or intramuscular opioid within 4 hours from procedure * New York Heart Association class ≥3 * acute unstable angina * acute myocardial infarction (confirmed by laboratory findings) in the past 6 weeks * heart rate (HR) ≤45-50 bpm * systolic blood pressure (SBP) ≤90 mm Hg, * 2nd or/and 3rd-degree Atrioventricular (AV) block (if the patient does not have a pacemaker) * severe functional liver or kidney disease, * obesity (body mass index ≥30 kg/m-2) * severe restrictive interstitial lung disease

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

PaO2/FIO2 ratio

Timeframe: measured before procedure, every 30 minutes during procedure, before discharge from the postanesthesia care unit (approximately 2 hours after end of procedure)

Trial details

NCT IDNCT03597828

SponsorAttikon Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2020-06-30

View on ClinicalTrials.gov More Pleural Effusions, Chronic trials