DC Vaccine in Pancreatic Cancer

Inclusion Criteria: * Pathologically-confirmed KRAS(G12D-), KRAS(G12V-), KRAS(G12R-) or KRAS(G12C-mutated) pancreatic ductal adenocarcinoma who are at high risk of relapse and have no evidence of disease. * Expression of one or more of the following HLA class I alleles: HLA-A02, HLA-A03, HLA-A11, HLA-B07 and HLA-C08. * Male or female, age 18+ * ECOG performance status 0-1 * Certain required laboratory values, performed within 14 days prior to consent * Subjects of reproductive potential must agree to use a medically accepted birth control method during the trial and for at least two months following the trial. * Provide written informed consent Exclusion Criteria: * Prior treatment with more than two lines of cytotoxic chemotherapy. Radiotherapy is not considered a line of therapy. * Prior malignancy (except non-melanoma skin cancer) within 3 years. * Pregnant or nursing women. * Concurrent treatment with systemic immunosuppressants, including corticosteroids (e.g prednisone), calcineurin inhibitors (e.g tacrolimus, cyclosporine), antiproliferative agents (e.g mycophenolate mofetil, azathioprine) within 2 weeks of eligibility confirmation. Local (inhaled or topical) steroids or replacement dose prednisone (≤ 10 mg daily) are permitted. * Known chronic viral infections including hepatitis B, hepatitis C, and HIV. * Known allergy to eggs. * Prior history of uveitis or autoimmune inflammatory eye disease. * Uncontrolled intercurrent illness. * Any condition that, in the opini…