Evaluate F901318 (Olorofim) Treatment of Invasive Fungal Infections in Participants Lacking Treatment Options

Inclusion Criteria: * Male and female aged at least 18 years, or male and female aged 16 years or 17 years and who weigh at least 40 kg whom have given informed consent * Ability and willingness to comply with the protocol. * Able to take oral medication * Females must be non-lactating and at no risk of pregnancy * Male with female partners of childbearing potential must either abstain from sexual intercourse or use a highly effective means of contraception * Participants with invasive fungal disease * Participants who have limited alternative treatment options Exclusion Criteria: * Women who are pregnant or breastfeeding. * Known history of allergy, hypersensitivity, or any serious reaction to any component of the study drug. * Participants with chronic aspergillosis, aspergilloma or allergic bronchopulmonary aspergillosis. * Human Immunodeficiency Virus (HIV) infection but not currently receiving antiretroviral therapy. * Participants with a medical condition that may jeopardize adherence to the protocol or may cause unacceptable additional risk to the participant * Previously enrolled participants or participants enrolled in any clinical trial within the last 30 days * Participants receiving treatment limited to supportive care due to predicted short survival time. * Prohibited concomitant medications. * Any exclusion criteria required by local regulatory authorities.