PrEvention of Posttraumatic Joint contractuRes With Ketotifen 2

Inclusion Criteria: * Age ≥ 18 years old; skeletally mature with no growth plates in the elbow * Distal humerus (AO/OTA type 13) and/or proximal ulna and/or proximal radius fractures (AO/OTA type 2U1 or 2R1) and/or elbow dislocations (open fractures with or without nerve injury may be included) * Operative treatment of the elbow fracture or dislocation * Injury ≤ 10 days * Participant has a negative urine or blood serum pregnancy test Exclusion Criteria: * Pre-existing elbow contracture * Elbow arthritis (osteoarthritis, inflammatory arthritis, or nonspecific monoarticular arthritis) * Inability to mobilize elbow within 21 days of injury * Bilateral elbow injury * Concomitant musculoskeletal or visceral injuries preventing post-operative elbow therapy * Oral hypoglycemic medications * History of epilepsy * Lactose intolerance * Language or Cognitive difficulties preventing reliable completion of questionnaires * Females who are pregnant or breast feeding * Females of reproductive age or males unwilling to use 2 effective methods of contraception * Severe renal impairment * Severe hepatic impairment * Prior elbow injury or operation * Total elbow replacement planned for treatment of injury * Unlikely to maintain follow up (no fixed address, plans to move out of town in the next year, states unable to comply with protocol) * Unwilling or unable to provide written informed consent for trial participation