Effects of Interleukin-1 Receptor Antagonism on Hyperandrogenemia in Women With Polycystic Ovary Syndrome

Inclusion Criteria: * Informed Consent as documented by signature * Premenopausal women aged 18 years or older * Onset of menarche ≥5 years ago * Diagnosis of PCOS defined by the Rotterdam criteria * High sensitivity C-reactive protein level ≥1 mg/l * Follicular phase of menstrual cycle as evident by * Serum estradiol level \<200 pmol/l AND * Serum progesterone level \<8 ng/ml * Willingness to use non-hormonal contraceptive measures adequate to prevent becoming pregnant during the study Exclusion Criteria: * Intake of any testosterone level modifying drugs in the 8 weeks prior to study inclusion, * Contraindications to the class of drugs under study, e.g. known hypersensitivity or allergy to Anakinra/Kineret, * Women who are pregnant or breast feeding, * Female participants who are ovariectomized or hysterectomised or post-menopausal * Known or suspected non-compliance, drug or alcohol abuse, * Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant, * Participation in another study with investigational drug within the 30 days preceding and during the present study, * Previous enrolment into the current study, * Enrolment of the investigator, his/her family members, employees and other dependent persons, * Clinical signs of infection in the week before inclusion or history of a severe infection during the last 2 months, * Potentially severe immunosuppression or intake of other immunosup…