Pharmacokinetic Study of Oral Gepotidacin (GSK2140944) in Subjects With Uncomplicated Urinary Tract Infection (Acute Cystitis)

Inclusion Criteria: * Subject must be \>=18 to \<=65 years of age inclusive, at the time of signing the informed consent. * The subject has 2 or more of the following clinical signs and symptoms of acute cystitis with onset \<=72 hours of the screening assessment: dysuria, frequency, urgency, or lower abdominal pain. * The subject has pyuria (\>=10 white blood cells per cubic millimeters \[WBC/mm\^3\] or the presence of leukocyte esterase) and/or nitrite from a pretreatment clean-catch midstream urine sample based on local laboratory procedures. * The subject is female. A female subject is eligible to participate if she is not pregnant, not breastfeeding, and at least 1 of the following conditions applies: a) Not a woman of childbearing potential (WOCBP) OR b) A WOCBP who agrees to follow the contraceptive guidance from the Baseline Visit through completion of the Test of Cure (TOC) Visit. * Capable of giving signed informed consent, which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and protocol. Exclusion Criteria: * The subject resides in a nursing home or dependent care-type facility. * The subject has a body mass index \>=40.0 kilogram per square meter (kg/m\^2) or a body mass index \>=35.0 kg/m\^2 with obesity-related health conditions such as high blood pressure or uncontrolled diabetes. * The subject has a history of sensitivity to the study treatment, or components thereof, or a history of a drug or other all…