Study to Evaluate CCS1477 in Advanced Tumours

Inclusion Criteria: * Provision of consent * ECOG performance status 0-1 * Assessable disease (by CT, MRI, bone scan or X-ray) * Adequate organ function * Highly effective contraception measures for duration of study Additional inclusion criteria for mCRPC patients only: * Previously received abiraterone and/or enzalutamide (or equivalent anti-androgen), and docetaxel (unless ineligible or refused) * Progressive disease documented by one or more of the following: * Biochemical progression defined as at least 2 stepwise increases in a series of any 3 PSA values * Progression as defined by RECIST v1.1 guideline for assessment of malignant soft tissue disease. * Progression defined as two or more new metastatic bone lesions confirmed on bone scan from a previous assessment * PSA at screening ≥2 μg/L * Serum testosterone concentration ≤50 ng/dL * Serum albumin \>2.5 g/dL Additional inclusion criteria for patients in CCS1477 plus abiraterone combination arm: * Patients must have previously progressed on abiraterone treatment * Patients whose last dose of abiraterone is greater than 6 months prior to start of study treatment will receive a 4-week run-in treatment with abiraterone to confirm refractoriness to abiraterone treatment Additional inclusion criteria for patients in CCS1477 plus enzalutamide combination arm: * Patients must have previously progressed on enzalutamide treatment * Patients whose last dose of enzalutamide is greater than 6 months prior to start o…