The aim of this study is to determine and compare serum cytokine levels of six different severe asthma inflammatory phenotypes differentiated by their atopy, peripheral eosinophilia and/or chronic rhinosinusitis and/or nasal polyposis status.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Patients diagnosed with severe asthma and followed-up at least 6 months at our clinic
✓. Asthma that can only be complete or partly controlled with Global Initiative for Asthma (GINA) 4-5 treatment
✓. Asthmatics that are eligible for the defined phenotypes
✓. At least one perennial allergen sensitivity for the atopic groups
✓. Non-asthmatics (without clinical and pulmonary function test evidence)
✓. Non-atopics (proved by skin prick tests)
✓. Serum eosinophil count \<300/cells
Exclusion criteria
✕. \<18 year-old
✕. Smoking history within the last 1 year prior to the study
✕. Asthmatics with inadequate inhaler technique and/or adherence problems