To compare FFR guided complete revascularization during the index procedure with usual care in non-STEMI patients with multivessel disease.
Who can participate
Age range
18 Years – 85 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients aged between 18-85 years presenting with non-STEMI according to current guidelines, who will be treated with PCI of the culprit and have at least one stenosis of \>50% in a non-IRA on QCA or visual estimation of baseline angiography and judged feasible for treatment with PCI by the operator.
* Non-IRA stenosis amenable for PCI treatment (operator's decision)
* Signed informed consent
Exclusion Criteria:
* Left main disease (stenosis \> 50%)
* Chronic total occlusion of a non-IRA
* Indication for or previous coronary artery bypass grafting
* Uncertain culprit lesion
* Complicated IRA treatment, e.g. extravasation, permanent no re-flow after IRA treatment (TIMI flow 0-1) and inability to implant a stent
* Known severe cardiac valve dysfunction that will require surgery or TAVI in the follow-up period.
* Killip class III or IV during the completion of culprit lesion treatment.
* Life expectancy of \< 1 year.
* Intolerance to Aspirin, Clopidogrel, Prasugrel, Ticagrelor or Heparin.
* Gastrointestinal or genitourinary bleeding within the prior 3 months.
* Planned elective surgical procedure necessitating interruption of thienopyridines during the first 6 months post enrolment.
* Patients who are actively participating in another drug or device investigational study, which have not completed the primary endpoint follow-up period.
* Pregnancy
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.