Mechanisms of Treatment Change in Panic Disorder and Agoraphobia

Inclusion Criteria: * A current DSM-IV diagnosis of panic disorder with agoraphobia that is designated by the patient as the most important source of current distress * Patients must be willing to engage in exposure to fearful situations and sensations Exclusion Criteria: * A history of bipolar disorder, psychosis or delusional disorders, current substance abuse or dependence Medical Exclusion Factors: * Patients with severe unstable medical illness, or serious medical illness for which hospitalization may be likely within the next three months * Patients with a history of seizures, angina, myocardial infarction, congestive heart failure, clinically significant arrhythmias, transient ischemic attacks, cerebrovascular accidents, diabetes mellitus, significant asthma, emphysema, or chronic obstructive pulmonary disease