The purpose of this study is to assess the safety, tolerability and antitumor activity of IMAB362 in Japanese subjects with locally advanced or metastatic Gastric or GEJ adenocarcinoma whose tumors have Claudin (CLDN) 18.2 Expression. This study will also assess pharmacokinetics and immunogenicity of IMAB362.
Age range
20 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Dose Limiting Toxicities (DLT) in Safety Part
Timeframe: Up to Day 22
Safety and tolerability assessed by incidence of adverse events (AEs) in Safety Part
Timeframe: Up to 16 months
Number of participants with laboratory test abnormalities in Safety Part
Timeframe: Up to 14 months
Number of participants with body weight abnormalities in Safety Part
Timeframe: Up to 14 months
Number of participants with vital sign abnormalities in Safety Part
Timeframe: Up to 14 months
Number of participants with 12-lead electrocardiogram (ECG) abnormalities in Safety Part
Timeframe: Up to 14 months
Safety assessed by Eastern Cooperative Oncology Group (ECOG) performance status in Safety Part
Timeframe: Up to 14 months
Objective Response Rate (ORR) by local review in Expansion Part
Timeframe: Up to 13 months