Acute Assessment of Platelet Reactivity After the Intake of Oleocanthal

Inclusion Criteria: * Trials 1 and 2: Male; Trial 3: Male and Female * 20-45 years old * For females, a regular 25-30-day menstrual cycle * Subject is willing and able to comply with the study protocols * Subject is willing to drink 40 mL (approximately 2 tablespoons) of olive oil * BMI 18.5 - 30 kg/m2 * Weight ≥ 110 pounds Exclusion Criteria: * Adults who are not able to consent * BMI ≥ 31 kg/m2 * Under current medical supervision * 1 ug/ml and 3 ug/ml collagen screening maximal platelet aggregatory response of \< 65%. * Platelet number or mean platelet values that are outside of the normal reference range as indicated on a complete blood cell count report from the UCD Med Center * Current diagnosis of anemia; or a screening hemoglobin and hematocrit that is less than the normal reference range. * Self-reported daily use of drugs that are known to affect platelet function, such as aspirin, Excedrin, and NSAIDS * Females using hormonal contraception * Ibuprofen intolerance or allergy * Those with a bleeding disorder * Non-English speaking * Allergy to olives or olive oil * Vegetarian, Vegan, food faddists, individuals using non-traditional diets, or on a weight loss diet. * A history of cardiovascular disease, stroke, cancer, renal, hepatic, or thyroid disease, GI tract disorders, previous GI surgery * Currently taking prescription drugs or supplements * Indications of substance or alcohol abuse within the last 3 years * Not willing to stop any supplement use, including he…