Impact of Escitalopram on Sperm DNA Fragmentation

Inclusion Criteria: * Normal semen analyses, or semen analyses with at least 5 million sperm * Normal TUNEL value (\<7%) * Willing to engage in at least weekly sexual activity, with a partner or alone for the duration of the 10-week study Exclusion Criteria: * Azoospermia or severe oligospermia (\<5million sperm per semen analysis) * Presently attempting to conceive pregnancy * Sexual dysfunction preventing ability to provide semen analysis throughout study or engage in weekly sexual activity * Current psychiatric disorder including: bipolar, mania, depression, generalized anxiety, social phobia, panic attacks, obsessive compulsive disorder, and schizophrenia. * Family history of bipolar disorder, or suicide (including 2nd degree relatives) * Present use of psychotropic agents (prescription or herbal) or anticonvulsants * Use of sleeping pills * Alcohol consumption greater that 2oz/day * Use of illicit drugs * Inability to read, follow instructions or complete questionnaires in English. * Use of hormonal medications in past 3 months (androgens, androgen blockade, anabolic steroids, estrogens, herbal) * Use of medications to enhance sexual function * History of chemotherapy or pelvic radiation * Use of Monoamine Oxidase inhibitors (MAOi's) or tricyclic antidepressants (TCAs) within 14 days * Liver disease