3BNC117 and 10-1074 in ART-treated Individuals

Inclusion Criteria: * Male and females, age 18 to 65. * Confirmed HIV-1 infection. * On antiretroviral therapy with plasma HIV-1 RNA levels of \< 50 copies/ml for at least 12 months, and \< 20 copies/ml at screening. Note: a single viral load measurement \> 50 but \< 500 copies/ml during this time period is allowed. * Current CD4+ T cell counts \> 500 cells/μl and CD4+ T cell count nadir of \> 200 cells/μl. * If on an NNRTI-based regimen, willing to switch to an integrase inhibitor-based regimen for at least 4 weeks prior to discontinuing ART * If sexually active male or female, participating in sexual activity that could lead to pregnancy and of reproductive potential, agrees to follow the contraception requirements outlined Section 6.12.12 Family Planning Counseling. Participants should also agree to use a male or female condom while off ART to prevent infecting sexual partners. Exclusion Criteria: * Have a history of AIDS-defining illness within 3 years prior to enrollment. * History of systemic corticosteroids (long term use), immunosuppressive anti-cancer, interleukins, systemic interferons, systemic chemotherapy or other medications considered significant by the trial physician within the last 6 months. * Any clinically significant acute or chronic medical condition (such as autoimmune diseases), other than HIV infection, that in the opinion of the investigator would preclude participation. * Hepatitis B or C infection as indicated by the presence of Hepatitis B surf…