CompletedNot Applicable

Evalutation of Insulin Sensitivity Through Hyperinsulinemic Clamp in Children With GH Deficiency

Italy23 participantsStarted 2014-01-01

Plain-language summary

Data about the impact of growth hormone treatment on insulin sensitivity in children are quite controversial, due to the different surrogate indexes that have been used, like Homa-IR, QUICKI, ISI-Matsuda or adipokine levels. The investigators aimed to evaluate insulin sensitivity through the euglycemic hyperinsulinemic clamp, considered the gold standard technique, in children affected by growth hormone deficiency and to compare the M-value with the most commonly used surrogate indexes of insulin sensitivity.

Who can participate

Age range5 Years – 10 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Isolated idiopathic GH deficiency diagnosed by the auxological and biochemical criteria of the GH Research Society in prepubertal children * Prepubertal children Exclusion Criteria: * Children with multiple hormone deficiency * Children receiving other hormonal replacement treatment * Pubertal children

What they're measuring

Change in insulin sensitivity in GHD children

Timeframe: baseline and after 12 months of GH treatment

Trial details

NCT IDNCT03525171

SponsorUniversity of Palermo

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2015-12-30

View on ClinicalTrials.gov More Growth Hormone Deficiency trials