A Study to Evaluate Ocrelizumab Treatment in Participants With Progressive Multiple Sclerosis

Inclusion Criteria: * Have a definite diagnosis of PMS (as per the revised McDonald 2010 criteria for PPMS or Lublin et al. 2014 criteria for PMS) * EDSS (Expanded Disability Status Scale) \</ =6.5 at screening * Have a documented evidence of disability progression independent of relapse at any point over the 2 years prior to the screening visit. In case relapse(s) have occurred in the last 2 years, disability progression will have to be considered as independent of relapse activity as per treating physician's judgment * Fulfill at least one of the 21 criteria assessing the evidence of disability progression independent of relapse activity in the last 2 years using the pre-baseline disability progression rating system checklist * Have experience of having used a smartphone and connecting a smartphone to Wi-Fi network providers * For women of childbearing potential: agreement to remain abstinent or use acceptable contraceptive methods during the treatment period and for at least 6 months, or longer if the local label is more stringent after the last dose of study drug Exclusion Criteria: * Relapsing-remitting multiple sclerosis (RRMS) at screening * Inability to complete an MRI * Gadolinium (Gd) intolerance * Known presence of other neurological disorders Exclusions Related to General Health: * Pregnancy confirmed by positive serum β human chorionic gonadotropin (hCG) measured at screening * Lactation * Any concomitant disease that may require chronic treatment of systemi…