Stopped: Per business decision, but not due to safety concerns or regulatory request.
The purpose of this clinical trial is to learn about the safety and effects of study medicine (PF-06873600) when taken alone or with hormone therapy by people with cancer. People may be able to participate in this study if they have the following types of cancer: Hormone Receptor positive (HR+) breast cancer; Human Epidermal Growth Factor Receptor 2 (HER2)-negative breast cancer that is advanced or metastatic (spread to other parts of the body); triple negative breast cancer; epithelial ovarian cancer; fallopian tube cancer; or primary peritoneal cancer. All participants in this study will receive the study medicine by mouth, 1 to 2 times a day at home. The dose of the study medicine may be changed during the study. Some participants will also receive hormone therapy. The hormone therapy will be either letrozole by mouth once a day at home, or fulvestrant as a shot into the muscle. Fulvestrant will be given every two weeks at the study clinic for the first month, and then once a month after that. Participants will take part in this study for at least 7 to 8 months, depending on how they respond to the therapy. During this time participants will visit the study clinic once a week for the first 2 cycles and every cycle thereafter.
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Number of Participants With Dose Limiting Toxicities (DLTs) - Part 1
Timeframe: Cycle 1 (within 28 days after the first dose of study intervention)
Number of Participants With Adverse Events (AEs) and Serious AEs (SAEs) - Part 1 + Part 2
Timeframe: Day 1 up to 28 days after the last dose of study intervention, up to approximately 24 months
Number of Participants With Worst Post-Baseline Hematology Results Based on Common Terminology Criteria for Adverse Events (CTCAE) Grade: Part 1 + Part 2
Timeframe: Day 1 up to 28 days after the last dose of study intervention, up to approximately 24 months
Number of Participants With Worst Post-Baseline Chemistry Results Based on Common Terminology Criteria for Adverse Events (CTCAE) Grade: Part 1 + Part 2
Timeframe: Day 1 up to 28 days after the last dose of study intervention, up to approximately 24 months
Number of Participants With Post-Baseline Vital Sign Abnormalities Meeting Pre-Defined Categorization - Part 1 + Part 2
Timeframe: Day 1 up to 28 days after the last dose of study intervention, up to approximately 24 months
Number of Participants With Post-Baseline Electrocardiogram (ECG) Changes Meeting Pre-Defined Categorization - Part 1 + Part 2
Timeframe: Day 1 up to 28 days after the last dose of study intervention, up to approximately 24 months
Overall Response Rate (ORR): Part 2
Timeframe: From the start of the treatment until disease/clinical progression or death or early study discontinuation, whichever happened earlier (approximately up to 24 months)