IFI16 is a Periodontitis Modulating Protein

Inclusion Criteria: * Subjects must have read, understood and signed an informed consent form. * Subjects must be able and willing to follow study procedures and instructions. * Subjects must be adult males or females with a minimum of 18 years (inclusive). * Subjects must present with at least 20 teeth in the functional dentition, excluding third molars. * Subjects must have at least 3 teeth in each posterior sextant * Subjects must be in good general health * Subjects must be in the healthy (PPC-A) or severe periodontitis (PPC-G) categories according to the PPC (1) Exclusion Criteria: * If the sextants identified for the analysis has implants * All individuals who meet criteria for anti-infective prophylaxis prior to dental procedures * Chronic disease with oral manifestations including diabetes mellitus. * Current smoker or one that has stopped smoking less than 2 years prior to enrollment. * Gross oral pathology other than the periodontal disease. * Treatment with antibiotics for any medical or dental condition within 1 month prior to the screening examination. * Chronic treatment (i.e., two weeks or more) with any medication known to affect periodontal status (e.g., phenytoin, calcium antagonists, cyclosporin, coumadin, non-steroidal anti-inflammatory drugs, aspirin) within one month of the screening examination. * Ongoing medications initiated less than three months prior to enrollment (i.e., medications for chronic medical conditions must be initiated at least three…