PRISM Study-Pruritus Relief Through Itch Scratch Modulation

Inclusion Criteria: * Individuals diagnosed with generalized nodular PN, covering 2 separate body parts, and 10 or more pruriginous nodules * Severe itch due to PN * Age 18 years and older at the time of consent, and a life expectancy of at least 18 months. * Individuals using antidepressants must be on a stable dose for a minimum of 4 weeks prior to screening. * Participants with a history of acute secondary dermatoses within the preceding 6 months may enroll only if the dermatosis has resolved completely as follows per medical history or participant self-report and current clinical assessment: (a) Localized contact dermatitis, environmental exposures, superficial burns, or viral exanthems must have been resolved for at least 4 weeks prior to screening. (b) Skin or environmental infestations, such as scabies, lice, or bed bugs, must have been resolved for at least 8 weeks prior to screening. * Any identified systemic, non-dermatologic disease that could be a potential cause of concomitant pruritus (e.g., thyroid disease, celiac disease, hepatitis C virus \[HCV\]) must either have resolved, been successfully treated \[i.e., HCV ribonucleic acid (RNA) negative\], or must be successfully managed with stable, optimized treatment (e.g., thyroid replacement, dietary management with resolution of symptoms, respectively) for at least 3 months prior to screening. * Participants who are human immunodeficiency virus (HIV) positive may enroll if they meet the following criteria: (a) cu…