Neodolpasse® Infusion Solution Versus Diclofenac 75 mg Infusion in the Treatment of Postoperative Pain After Elective Knee Surgery

Inclusion Criteria: * Elective cruciate ligament surgery * Confirmed patient suitability for planned surgery * Legally valid signed written informed consent provided * Female patients are confirmed non-pregnant (negative pregnancy test) or not breast feeding * Adequate renal function defined by a creatinine value lower than 1.80 mg/dL for male and ower than 1.50 mg/dL for female patients * No known intolerabilities or hypersensitivities to any part of the IMP / control medication * No reoperation/revision within 6 months after the initial surgery * Absence of history of abuse of analgesics or other drug * No analgesics within 48 hours prior to surgery (surgery-related medication excluded) * No current / recent (within 4 weeks prior to enrolment) experimental treatment * No current / recent (within 4 weeks prior to enrolment) participation in another clinical study * No foreseeable difficulties with regard to protocol compliance * No known hypersensibility against the active ingredients diclofenac, orphenadrine, remifentanil, propofol, rocuronium, and hydromorphone * No known hypersensibility against the other ingredients of the investigational medicinal product * Absence of congestive heart failure classes 2 or higher according to the NYHA classification * Absence of ischemic heart disease * Absence of peripheral arterial occlusive disease * Absence of cerebro-vascular disease * Absence of significant risk factors for cardiovascular events (e.g., hypertension, hyperlipidaemi…