Effects of Soccer Heading on Ocular-motor Function and Blood Biomarker (NCT03488381) | Clinical Trial Compass
CompletedNot Applicable
Effects of Soccer Heading on Ocular-motor Function and Blood Biomarker
United States45 participantsStarted 2017-08-01
Plain-language summary
Repetitive head impacts in sports and military may cause deleterious effects in the nervous system. Investigators' previous works in football players have shown promising results in prediction of concussion and prevention of long-term defect using eye-movement paradigm (ocular-motor system) and blood biomarker. However, acute head impact effects on aforementioned parameters remain unknown. Thus, to answer a critical research question that whether or not ocular-motor system and brain-derived blood biomarker may be acutely altered following 10 successions of controlled soccer heading. To answer the question, investigators hypothesized that acute bout of soccer heading will not elicit noticeable change in subject's symptoms but to induce a transient defect in the ocular-motor system and increase plasma expression of brain-derived biomarker.
Who can participate
Age range18 Years – 26 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. being between 18 to 26 years of age
✓. an active member of a soccer team (i.e., collegiate, intramural, club, professional)
✓. at least 5 years of soccer heading experience.
✓. Being between 18 to 26 years of age
✓. Have never played organized sports
✓. Have never been diagnosed with a concussion
Exclusion criteria
✕. any head, neck, or face injury in the 1 year prior to the study (e.g., concussion, eye injury);
✕. history of vestibular, ocular, or vision dysfunction (e.g., macular degeneration)
✕. currently taking any medications affecting balance (e.g., antibiotics)
✕. pregnancy
✕. HIV
What they're measuring
1
Changes in Brain-Derived Blood Biomarker Over Time in Relation to the Baseline
Timeframe: Measured at four time points (pre-intervention, immediately post-intervention, 2 hours post, and 24 post)
2
Changes in Ocular-Motor Function Over Time in Relation to the Baseline
Timeframe: Measured at four time points (pre-intervention, immediately post-intervention, 2 hours post, and 24 post)
✕. any neurological disorders (e.g., seizure disorders, closed head injuries with loss of consciousness greater than 15 minutes, CNS neoplasm, spinal cord injury/surgery, history of stroke)
✕. hypertension, cardiac arrhythmia, or pulmonary disease
✕. lower extremity injury that would prohibit normal walking