White Matter Hyperintensities Burden in Adult Patients With Cyanotic Congenital Heart Disease: a … (NCT03487302) | Clinical Trial Compass
CompletedNot Applicable
White Matter Hyperintensities Burden in Adult Patients With Cyanotic Congenital Heart Disease: a Pilot Study
Italy146 participantsStarted 2017-10-17
Plain-language summary
The study aims at investigating the role of cyanotic congenital heart disease (cCHD) on brain aging. The investigators assume that due to congenital and acquired cardiovascular abnormalities, cCHD patients could show radiologic (and clinical) signs of precocious brain aging and eventual cognitive decline.
Who can participate
Age range20 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* for the patient group, being an adult subject affected with cyanotic congenital heart disease, whether surgically corrected or not.
* for the control group, being an healthy subject.
Exclusion Criteria:
* any contraindication to magnetic resonance imaging;
* any pathological condition and/or symptomp that could alter the white matter hyperintensities burden, among which:
* inflammatory, infectious, demyelinating or dysmyelinating diseases of the CNS;
* ischemic, haemorrhagic or traumatic brain events and eventual gliotic and malacic or lacunar sequelae;
* genetic diseases (whether mendelian or mitochondrial) of the CNS;
* cerebral amyloid angiopathy;
* CADASIL;
* cerebral arteriovenous malformations;
* primary or metastatic brain neoplasms which cause neurological symptoms and/or brain parenchymal sequelae from surgical excision;
* patent oval foramen;
* being pregnant;
* migraine with aura (Bashir, Lipton, Ashina, \& Ashina, 2013).
What they're measuring
1
White matter hyperintensities volume expressed in mm^3