Study of PSMA-targeted 18F-DCFPyL PET/CT for the Detection of Clinically Significant Prostate Cancer

Inclusion Criteria: * ≥18 years of age * PSA of 2-10 ng/mL * Clinical stage T1c-T2a on digital rectal exam * Elect to undergo TRUS-guided prostate biopsy as part of routine clinical care * Willingness to sign informed consent and comply with all protocol requirements Exclusion Criteria: * History of prior prostate biopsy * Administered a radioisotope ≤5 physical half-lives prior to the date of study PET/CT * Administered IV X-ray contrast medium ≤24 hours prior to the date of study PET/CT * Administered oral contrast medium ≤120 hours prior to the date of study PET/CT * Any medical condition or other circumstances that in the opinion of the investigators compromise obtaining reliable data or achieving the study objectives