Evaluating the Live-Attenuated Human Parainfluenza Virus Type 3 Vectored Vaccine Candidate Expressing Ebolavirus Zaire Glycoprotein as the Sole Envelope Glycoprotein

Inclusion Criteria: * Adult males and non-pregnant females between 18 and 50 years of age inclusive * General good health, without significant medical illness, physical examination findings, or significant laboratory abnormalities as determined by the investigator * Agree to storage of blood specimens for future research * Available for the duration of the trial * Able to demonstrate understanding of key study concepts, study rationale, and study participation requirements by scoring greater than or equal to 70% on a written comprehension assessment in less than or equal to 3 attempts. * Willingness to participate in the study as evidenced by signing the informed consent document * Female subjects of childbearing potential must agree to have used effective birth control methods beginning at least one month prior to vaccination, and continuing with 'per label/fully effective use' for the chosen method for the duration of the study, from amongst these: * pharmacologic/hormonal contraceptives, including oral, parenteral, subcutaneous, and transcutaneous delivery; * condoms with spermicide; * diaphragm with spermicide; * intrauterine device; * absolute abstinence from heterosexual intercourse as a matter of normal preferred lifestyle; * or must be surgically sterile, or must be age 50 AND have had no menses at all for at least one full year. * All females must provide samples for urine and serum pregnancy testing prior to enrollment (immediately prior to each vacc…