Safety, Efficacy of FFP From Healthy Donors to Ameliorate Frailty and Enhance Immune Function in Older Individuals

Inclusion Criteria: * Provide written informed consent. * Be aged between 55-95 years. * Show signs of frailty apart from a concomitant condition as assessed by the Investigator with a score of 4-7 on the Clinical Frailty Scale (Appendix 1) and/or Have an abnormal Immune Risk Profile (IRP) * Not be pregnant or nursing while participating in this trial. Both men and women of reproductive potential must agree to use an effective means of birth control while participating in the trial. Women of childbearing potential should have a negative serum pregnancy test before treatment, if not surgically sterile. * Have a negative neutrophil antibody test. * Have a negative Human Leukocyte Antigen (HLA) Class I and II antibody test. * Have Cytomegalovirus (CMV) negative or positive sero-testing completed. * Have a life expectancy of at least 24 months as judged by the PI at the time of consent. * Have less than 4 weeks since prior medical therapy, radiation therapy, and/or surgery * Have adequate organ function including: Hemoglobin greater than 10.0 g/dl Absolute neutrophils must be greater than 1,500/Microliter(uL) Platelet count must be greater than100,000/uL Serum bilirubin must be less than 2mg/dL Aspartate Aminotransferase (AST) must be less than 90 units/L Alanine Transaminase (ALT) must be less than 105 units/L Serum creatinine must be less than 2mg/dL Exclusion Criteria: * Have a score of less than 4 or greater than 7 on the Clinical Frailty Scale or Have a score of less tha…