T-VEC in Non-melanoma Skin Cancer

Inclusion Criteria: * Subjects Age ≥ 18 years * histologically confirmed diagnosis of locally advanced squamous cell carcinoma, basal cell, carcinoma, Merkel cell carcinoma or cutaneous T cell lymphoma * at least 1 injectable cutaneous lesion ≥ 20 mm in longest Diameter or multiple injectable lesions that in Aggregate have a longest Diameter of ≥ 50 mm * Eastern Cooperative Oncology Group-Status (ECOG Status) 0 or 1 * Adequate organ functions Exclusion Criteria: * Hypersensitivity to T-VEC or any of ist components * Presence of organ and lymph node metastases * history or evidence of active autoimmune disease that requires systemic Treatment * Evidence of clinically significant immunosuppression * active herpetic skin lesions or prior complications hereof * pregnancy, breast feeding * requires intermittent or chronic systemic Treatment with an antiherpetic drug * acute or chronic active Hepatitis B or C infection or HIV infection