This 2-part study will be carried out on healthy elderly subjects to evaluate relative bioavailability of danirixin formulations. Part A will support the selection of the formulation and Part B will assess food effect, bioavailability and pharmacokinetic (PK) profile of selected formulation from Part A. Danirixin is currently administered with food, therefore the investigation of food effect for the selected formulation could potentially enable dosing without food. Approximately 16 subjects will be included in Part A and approximately 24 subjects will be included in Part B. Both parts will include a screening phase, treatment phase with in-between washout period and a follow-up phase.
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Area Under the Concentration-time Curve From Time 0 to Infinity (AUC [0-inf]) of Danirixin for Part 1
Timeframe: Pre-dose and 0.5, 1, 1.5, 2, 3, 4, 6, 8, 10, 12, 24, 48 hours in Part 1
Maximum Observed Concentration (Cmax) of Danirixin for Part 1
Timeframe: Pre-dose and 0.5, 1, 1.5, 2, 3, 4, 6, 8, 10, 12, 24, 48 hours in Part 1
Number of Participants With Any Adverse Event (AE) and Serious Adverse Events (SAEs) in Part 1
Timeframe: Up to 29 days in Part 1
Number of Participants With Vital Signs of Potential Clinical Concern in Part 1
Timeframe: Up to 29 days in Part 1
Number of Participants With 12-lead Electrocardiogram (ECG) Values of Potential Clinical Concern in Part 1
Timeframe: Up to 29 days in Part 1
Number of Participants With Laboratory Values of Potential Clinical Concern in Part 1
Timeframe: Up to 29 days in Part 1