CompletedNot Applicable

Synbiotic as an Adjunct to Mechanical Treatment of Gingivitis

80 participantsStarted 2014-07-22

Plain-language summary

The aim of this study is to evaluate the efficacy of oral administration of synbiotic tablets on the clinical parameters and the levels of selected inflammatory mediators in gingival crevicular fluid (GCF) in smokers and non-smokers with gingivitis. This study designed as a double-blind randomized placebo-controlled clinical trial.

Who can participate

Age range18 Years – 30 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Systemically healthy subjects * Clinical diagnosis of gingivitis Exclusion Criteria: * Subjects who had used any systemic antibiotics in the previous 3 months, * Subjects who had used a product containing probiotics in the previous month * Systemic disease or condition that could interfere with the study results * Ongoing drug therapy that could affect the signs of gingivitis * Subjects who were received periodontal treatment in the last 6 months and * Allergic to milk and milk products

What they're measuring

Change from Baseline Interleukin (IL)-6 level of GCF at 2 months

Timeframe: baseline, 1st and 2nd months

Change from Baseline IL-8 level of GCF at 2 months

Timeframe: baseline, 1st and 2nd months

Change from Baseline IL-10 level of GCF at 2 months

Timeframe: baseline, 1st and 2nd months

Trial details

NCT IDNCT03455192

SponsorKırıkkale University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2015-06-29

View on ClinicalTrials.gov More Gingivitis; Chronic trials