SOD1 Kinetics Measurements in ALS Patients

Inclusion Criteria (with exceptions for each group): * Males or females of any race aged 18 or older * Positive for SOD1 mutation (SOD1 ALS only) * Diagnosed with Definite, Probable or Possible ALS in accordance with El Escorial criteria (ALS and SOD1 Positive ALS only) * Able to hold position and breathe comfortably for the duration of the LP procedure as determined by the LP physician or Nurse Practitioner * Subjects must be able to provide informed consent Exclusion Criteria for all groups: * Invasive ventilator dependence, such as tracheostomy * Medically unable to undergo lumbar puncture (LP) as determined by the investigator (i.e.,bleeding disorder, allergy to local anesthetics, a skin infection at or near the LP site, or evidence of high intracranial pressure). * Any active dermatologic disease. * Any connective tissue disease including systemic lupus erythematous, Sjögren's syndrome, scleroderma or mixed connective tissue disease. * Any known or suspected abnormal CSF pressure or intracranial/intraspinal tumors. * Use of anticoagulant medication (eg. warfarin, dalteparin, enoxaparin, rivaroxaban, fondaparinux, dabigatran) that cannot be safely withheld until coagulation parameters have normalized prior to lumbar puncture and for up to a week following the lumbar puncture. * Blood dyscrasia, abnormal bleeding diathesis, or the use of dialysis for renal failure. * Clinical judgment of the Site Investigator that the subject would be unable to undergo multiple lumbar p…