Evaluation of Safety and Feasibility of EUS-guided RFA for Solid Pancreatic Neoplasms

Inclusion Criteria: * Age 21 years-old or above * Suffering from pancreatic neuroendocrine tumour or pancreatic ductal carcinoma that was confirmed by fine needle aspiration cytology * Unsuitable for surgery, due to one (or more) of the following items: * ASA score \>/= III * An alternative advanced malignancy * Unsuitable for surgery upon expert's opinion for any other reason * Individuals who are not keen for surgical resection * Eligible for endoscopic intervention * Written informed consent Exclusion Criteria: * Coagulopathy (international normalized ratio \>1.5, partial thromboplastin time greater than twice that of control), platelet count \<50,000x103/uL * Pregnancy * Patients with a poor mental condition or mental retardation, unable to understand the nature and possible consequences of the study * Patients unwilling to undergo follow-up assessments * Patients with liver cirrhosis, portal hypertension and/or gastric varices.