Peripheral Blood Stem Cell Transplantation From Family Haploidentical Donors in Patients With Myelodysplastic Syndrome and Acute Leukemia Under Primary Prophylaxis With Posaconazole

Inclusion Criteria: * Diagnosis of myelodysplastic syndromes or acute leukemia * Activation of an alternative donor search by the Italian Bone Marrow Donor Registry (IBMDR) with absence of a 10/10 Human Leukocyte Antigens (HLA) matched unrelated donor * Age \>18 * Unavailability of a HLA-matched related donor (MRD) * Performance status : Eastern Cooperative Oncology Group (ECOG) \<3 * Written and signed informed consent * Life expectancy not severely limited by concomitant illness. Exclusion Criteria: * Women of child-bearing potential who do not agree to abstinence or, if sexually active, do not agree to the use of highly effective method of birth control such as condoms, implants, injectables, combined oral contraceptives, intrauterine devices (IUDs), vasectomised partner on treatment and for at least 6 months thereafter. * Pregnant or nursing (lactating) women. * Known allergies, hypersensitivity, or intolerance to any experimental drugs. * Any active, uncontrolled infection.