Safety of Autologous Cord Blood Cells in HLHS Patients During Norwood Heart Surgery

Inclusion Criteria: * Male and females with antenatally diagnosed Hypoplastic Left Heart Syndrome (all types requiring Norwood operation) * Written informed consent by parents/legal guardian * Successful aseptic collection of autologous cord blood unit and transfer of buffy coat mononucleocyte fraction to cold storage pending cardiac surgery within 2-4 days Exclusion Criteria: Patient: * does not have autologous cord blood cells available at the time of cardiopulmonary bypass surgery * has evidence of arrhythmia requiring anti-arrhythmia therapy * has an additional congenital diagnosis that contributes to conditions such as an immune system disorder, immune deficiency, complex metabolic disorder, brain dysplasia or progressive neurological degenerative disorder * has other clinical complexity deemed by the cardiac surgeon to make the patient unsuitable for inclusion in the trial Mother: • is serum positive for HIV, hepatitis or other significant pathogen and has known allergies to penicillin, streptomycin or other antibiotic