Safety and Performance Study of Large Hole Vascular Closure Device FIV

Inclusion Criteria: * Over 18 years of age. * Subject is willing and able to provide appropriate study-specific informed consent, follow protocol procedures, and comply with follow-up visit requirements. * Clinically indicated for an endovascular procedure using a common femoral arteriotomy created by a 12 - 20 F sheath. Exclusion Criteria: * Severe acute non-cardiac systemic disease or terminal illness with a life expectancy of less than six months. * Evidence of systemic bacterial or cutaneous infection, including groin infection. * Known bleeding diathesis, definite or potential coagulopathy, platelet count \< 100,000/μl or patients on long term anticoagulants with an INR greater than 1.2 at time of procedure or known type II heparin-induced thrombocytopenia. * Severe; claudication or peripheral vascular disease (e.g. Rutherford category 3 or greater or ABI \< 0.5), documented untreated iliac artery diameter stenosis \> 50% or previous bypass surgery/stent placement in the common femoral artery of ipsilateral limb. * Known allergy to any of the materials used in the PerQseal®. * Subject has undergone a percutaneous procedure using a non-absorbable vascular closure device (excluding suture mediated) for haemostasis in the ipsilateral target leg. * Patients that have undergone a percutaneous procedure in the ipsilateral leg, within the previous 30 days. * Patients that have undergone a percutaneous procedure using an absorbable intravascular closure device for haemostasis…