Management of Malignant Pleural Effusions Using an Indwelling Tunneled Pleural Catheter and Non-Vacuum Collection System

Inclusion Criteria: * Male or female, at least 18 years of age, inclusive * Subject has a symptomatic malignant pleural effusion requiring intervention. For an effusion to be defined as malignant, at least one of the following must be true * There is cytological confirmation of pleural malignancy * The effusion is an exudate (per Light's criteria Pleural fluid protein/Serum protein \>0.5, Pleural fluid LDH/Serum LDH \>0.6, or Pleural fluid LDH \>2/3 the upper limit of normal) in the context of histocytologically proven malignancy elsewhere, with no other clear cause for fluid identified * Subject is able to provide informed consent * Subject has sufficient pleural fluid to allow safe insertion of an indwelling tunneled pleural catheter as determined by the PI * Subject is able to perform home drainage of the pleural effusion or has sufficient resources (family member, caregiver, home health). Exclusion Criteria: * Subject is pregnant * Subject has evidence, in the opinion of the PI, of either ongoing systemic or pleural infection * Subjects with uncorrected coagulopathy