Red Maple Trials Cat Allergen Natural Exposure Chamber Validation in Cat-allergic Subjects

Inclusion Criteria for Allergic Subjects: * Male and female adults, 18 years to 65 years of age * Willing and able to give informed consent for participation in the study. * Otherwise healthy with a diagnosis of perennial allergic rhinitis and a clinical history of nasal symptoms during exposure to cat in the previous 2 years * With positive skin prick test reactivity to cat dander. A positive skin prick test is a wheal ≥3 mm larger than the negative control performed at the screening visit or within 6 months of the screening visit provided that complete documentation (specific allergen used for the SPT and the size of the reaction) is available * Having sufficient rhinoconjunctivitis symptoms (TRCSS score ≥5) during the first cat challenge * If subjects are taking medications (other than allergy medications), the dosing must be stable for at least 4 weeks prior to study entry * With laboratory results at the screening visit which, in the opinion of the investigator, are clinically acceptable for the subject to be enrolled in the study * Able (in the investigators opinion) and willing to comply with all study requirements Exclusion Criteria for Allergic Subjects: * Subjects with a cat at home or who are regularly exposed to cats during the study period * Subjects with a diagnosis of asthma with the exception of mild intermittent asthma defined as normal lung function and intermittent treatment with a short-acting beta agonist only * Subjects with a history of anaphylactic …