Perfusion CT in Predicting Outcomes in Ovarian, Fallopian, or Peritoneal Cancer With Bevacizumab (NCT03412630) | Clinical Trial Compass
TerminatedNot Applicable
Perfusion CT in Predicting Outcomes in Ovarian, Fallopian, or Peritoneal Cancer With Bevacizumab
Stopped: poor accrual
United States1 participantsStarted 2018-12-13
Plain-language summary
This phase II trial studies how well computed tomography perfusion imaging works in predicting outcomes in patients with ovarian, fallopian tube, or primary peritoneal cancer who are receiving bevacizumab. Computed tomography perfusion imaging monitors the effects of the drug treatment on the blood flow to the tumor, and may help to predict whether a certain drug therapy is likely be successful in a patient with ovarian, fallopian tube, or primary peritoneal cancer.
Who can participate
Age range18 Years
SexFEMALE
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Inclusion Criteria:
* REGISTRATION TO STEP 0
* Patient must have epithelial ovarian, fallopian tube, or primary peritoneal cancer
* Patients with non-epithelial tumors or tumors with low malignant potential are excluded
* Patient must have suspected platinum-resistant disease (disease progression =\< 6 months of platinum therapy)
* Patient must be expected to undergo therapy with bevacizumab in combination with paclitaxel, pegylated liposomal doxorubicin (PLD), or topotecan at recommended standard of care doses if suspected recurrence is confirmed with imaging
* Patient must be able and willing to provide written informed consent
* Patient must have a life expectancy of \>= 3 months
* Patient must have adequate bone marrow, coagulation, renal, and hepatic function
* Patient must demonstrate an Eastern Cooperative Oncology Group (ECOG) performance status of 0-2
* Patient must not have undergone therapy with any anti-VEGF drug within previous 6 months
* Patient must not have undergone major surgery or radiotherapy to the pelvis or abdomen within previous 4 weeks
* Patients must not have known contraindications to bevacizumab, including but not limited to abdominal fistula, gastrointestinal (GI) perforation, intra-abdominal abscess, thrombotic or hemorrhagic disorders, uncontrolled hypertension or active clinically significant cardiovascular disease, non-healing wound, ulcer, or bone fracture within previous 4 weeks
* Patient must not have untreated or symptomatic central ne…
What they're measuring
1
Progression Free Survival (PFS)
Timeframe: Time to progression or death from the T1 scan, assessed up to 18 months