Intermittent Fasting Versus Daily Caloric Restriction for Weight Loss

Inclusion Criteria: * Female or Male * Age 18-60 years * Body Mass Index 27-46 kg/m2 * Sedentary: defined as \<150 minutes per week of voluntary exercise at moderate intensity or greater and \< 60 min per day of total habitual physical activity (i.e. work related, transportation related) at moderate intensity or greater, over the past 3 months. * No self-report of acute or chronic disease (cardiovascular disease (CVD), diabetes, gastrointestinal disorders and orthopedic problems in particular) * No plans to relocate within the next 12 months * No plans for extended travel (\> 2 weeks) within the next 12 months * No nicotine use * Live or work within 30 minutes of the Anschutz Health and Wellness Center (AHWC) (exceptions may be made at the discretion of the Study PI on a case by case basis for highly motivated subjects). * Capable and willing to give informed consent, understand exclusion criteria, and accept the randomized group assignment. * Have a primary care physician (or are willing to establish care with a primary care physician prior to study enrollment) to address medical issues which may arise during screening or study procedures/interventions. * For Females * Not currently pregnant or lactating * Not pregnant within the past 6 months * Not planning to become pregnant in the next 12 months; * Sexually active women of childbearing potential may be enrolled if they have had a tubal ligation or use a reliable means of contraception Exclusion Criteria * Dias…