Short Course Regimens for Treatment of PKDL (Sudan)

Inclusion Criteria: * Confirmed PKDL case by clinical presentation and demonstration of parasites by microscopy in a skin smear or by PCR, with documented stable or progressive disease for at least 6 months or grade 3 PKDL * Male or Female patients aged 6 to 60 years * Written voluntarily informed consent is obtained from the patient, or his guardian if the patient is \< 18 years old. In the case of minors aged \>12 to \<18, assent from the children is also needed in addition to the guardian's consent. Exclusion Criteria: * Patients who had prior treatment of PKDL within the last 1 year * Pregnant and lactating women and women of childbearing age (12 to 55 years) who do not accept to have a pregnancy test and who do not agree to use contraception during treatment period and for 5 months after the end of treatment. * Patients with signs and symptoms of severe diseases: defined as suffering from a concomitant severe infection such as TB or any other serious known underlying disease (cardiac, renal, hepatic), * Severe malnutrition defined by BMI for age WHO reference curves for gender, Z score \< -3 for subjects 6 to \< 19 years; BMI \< 16 for subjects \> 19 years old * Patients with haemoglobin \< 5g/dL * Patients with known skin disease * Patients with abnormal liver function (ALT and AST) tests of more than three times the normal range. * Patients with total bilirubin levels \>1.5 times the upper normal range * Patients with serum creatinine above the upper limit of normal…