Aggressive Antipyretics for Fever Reduction in CNS Malaria

Inclusion Criteria: * Evidence of Plasmodium falciparum malaria infection by peripheral blood smear or rapid diagnostic test * Central nervous system (CNS) symptoms associated with malaria. CEREBRAL MALARIA (CM): Impaired consciousness with a Blantyre Coma Score (BCS)(73) ≤2 in children under 5 years or a Glasgow Coma score (GCS) ≤10 in children ≥5 years OR CNS MALARIA: Complicated seizure(s), meaning prolonged (\>15 minutes), focal or multiple; or impaired consciousness or other evidence of impaired consciousness (confusion, delirium) without frank coma (BCS\>2, GCS =11-14) Exclusion Criteria: * Circulatory failure (cold extremities, capillary refill \> 3 seconds, sunken eyes, ↓ skin turgor) * Vomiting in the past 2 hours * Serum creatinine (Cr) \> 1.2 mg/dL * A history of liver disease * Jaundice or a total bilirubin of \>3.0mg/dL * A history of gastric ulcers or gastrointestinal bleeding * A history of thrombocytopenia or other primary hematologic disorder * Petechiae or other clinical indications of bleeding abnormalities * A known allergy to ibuprofen, acetaminophen, aspirin or any non-steroidal medication * Any contraindication for nasogastric tube (NGT) placement and/or delivery of enteral medications