Role of Prophylactic Metoclopramide With Tramadol in Trauma Patients (NCT03383315) | Clinical Trial Compass
CompletedPhase 2
Role of Prophylactic Metoclopramide With Tramadol in Trauma Patients
Malaysia191 participantsStarted 2017-07-01
Plain-language summary
Tramadol is widely used as analgesic in trauma patients. However, it causes side effects, most notably nausea and vomiting. This study aim to determine the role of prophylactic metoclopramide in preventing tramadol induced nausea and vomiting.
Who can participate
Age range18 Years
SexALL
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Inclusion Criteria:
* Patients aged 18 years or older on day of presentation to ETD SGH
* Sustained from traumatic injuries of extremities (Fracture of hand \& wrist, radius, ulna, humerus, femur, tibia, fibula and/or foot \& ankle; laceration wounds of extremities; soft tissue injury)
* Patient who is able to give consent
Exclusion Criteria:
* Known allergy to metoclopramide
* Concurrently taking medication with anti-emetic effect, including antihistamines, phenothiazines and dopamine antagonists.
* A history of vomiting since time of injury
* Patients who had already received tramadol or metoclopramide in the previous 8 hours prior to arrival at ETD
* Below age of 18 on day of presentation, or patients who could not consent to the study
* Any alteration in level of consciousness
* Hemodynamic instability or primary diagnosis requiring time critical intervention
* Pregnancy or lactation
* History or known case of vertiginous disorder
* Currently undergoing chemotherapy or radiotherapy