A Study of BAX 888 in Male Adults With Severe Hemophilia A

Inclusion Criteria: * Male, aged 18 to 75 years at the time of screening. * Established severe hemophilia A (FVIII:C \<1%, measured following \>=5 days without FVIII treatment) and/or documented intron 1 inversion or intron 22 inversion mutation in the F8 gene, consistent with severe hemophilia A , and documented evidence of \>=3 hemorrhages over the previous 12 months requiring treatment with exogenous FVIII or use of FVIII prophylaxis because of history of frequent bleeding episodes. * History of greater than (\>) 150 exposure days to exogenously administered FVIII concentrates or cryoprecipitate. * Sexually active men must agree to use barrier contraception (combination of a condom and spermicide) or limit sexual intercourse to post-menopausal, surgically sterilized, or contraception-practicing partners for a minimum of 6 months after administration of BAX 888, or until BAX 888 genomes are no longer detected in the semen, whichever is sooner. * Participant is willing and able to comply with the requirements of the protocol, including provision of semen samples, maintenance of a diary of bleeding episodes and FVIII protein use. * Signed informed consent. Exclusion Criteria: * Bleeding disorder(s) other than hemophilia A. * Personal laboratory evidence of having developed inhibitors to FVIII protein at any time (\>=0.6 Bethesda units \[BU\] on any single test). * Documented prior allergic reaction to any FVIII product. * Anti-Adeno-associated virus, serotype 8 (AAV8) neut…