Fecal Microbiota Transplantation (FMT) for MDRO UTI

Inclusion Criteria: * Age ≥18 years old. * Outpatient status at time of FMT. * History of at least three recurrent UTIs due to an MDRO; at least two recurrent, severe infections due to MDRO requiring hospitalization; or at least two recurrent infections due to MDRO for which only antimicrobials with rate limiting toxicities (see above) are available. * Be without active infection due to the MDRO at the time of FMT. * Not be receiving antimicrobials (therapeutic or suppressive) within 48 hours of FMT. Exclusion Criteria: * Age \<18 years * Inpatient status at time of FMT * Ineligible UTI * \>1 organism in urine (other than minimal contaminants) * Decline to participate * Recurrent Clostridium difficile infection * Presence of intra-abdominal devises * Neutropenia (ANC \<500 mm3) * Intestinal mucosal disruption * Unlikely to survive 6 months * Pregnancy or unwillingness to use contraceptives * Short gut syndrome * Use of medications that affect intestinal motility * Gastrointestinal motility disorder * Inflammatory bowel disease * Recent abdominal surgery * Active typhlitis * Active diverticulitis * Current gastrointestinal graft versus host disease * HIV with lack of antiretroviral therapy (ART) * CD4 count \<200 mm3 * Peritoneal dialysis * Cirrhosis with ascites * Active intra-abdominal malignancy * Presence of chronic indwelling foley catheter, chronic suprapubic catheter, or ileal conduit * Active hepatitis C * Active hepatitis B * Presence of ureteral stent * Active kid…