Cellular Immunotherapy in Recipients of HLA-matched, Living Donor Kidney Transplants

Recipient Inclusion Criteria: * Planned recipient of a first kidney allograft from an HLA-matched, living related donor * Age ≥18 and ≤70 years * Single solid organ recipient (kidney only) * ABO matched with donor Recipient Exclusion Criteria: * Underlying kidney disease with a high risk of disease recurrence in the transplanted kidney * Baseline positive donor-specific anti-HLA antibody testing * Is taking immunosuppressive therapy * Evidence of prior hepatitis B (HBV) or hepatitis C (HCV) Donor Inclusion Criteria: * HLA-matched first degree (parent, child or sibling) or second-degree (child of a sibling or half sibling) relative of the prospective recipient participant * Age ≥18 and ≤70 years * Prepared to be a living related kidney donor, and capable of undergoing G-CSF mobilization and apheresis of hematopoietic cells Donor Exclusion Criteria: * History of autoimmune disorders * History of type 1 or type 2 diabetes mellitus * Tests confirmed positive for human immunodeficiency virus (HIV), HBV, HCV, T. cruzi, or syphilis * History of infection with Zika virus