Study of ARO-AAT in Normal Adult Volunteers

Inclusion Criteria: * Women of child bearing potential must have a negative pregnancy test, cannot be breastfeeding, and must be willing to use contraception * Willing to provide written informed consent and to comply with study requirements * Non-smoker for at least one year * Normal lung function * No abnormal finding of clinical relevance at Screening * Normal AAT level at Screening visit Exclusion Criteria: * Clinically significant health concerns * Regular use of alcohol within one month prior to Screening * Use of an investigational agent or device within 30 days prior to dosing or current participation in an investigational study * Recent use of illicit drugs * Use of any drugs or dietary/herbal supplements know to interfere with liver metabolism NOTE: additional inclusion/exclusion criteria may apply, per protocol