Perinatal Arterial Stroke Treated With Stromal Cells Intranasally

Inclusion Criteria: * (Near-)Term infants, ≥36+0 weeks of gestation, admitted to one of the Dutch Neonatal Intensive Care Units, diagnosed with PAIS, confirmed by MRI within 3 days after presentation with clinical symptoms. * PAIS as characterized by a predominantly unilateral ischemic lesion within the territory of the middle cerebral artery, with involvement of the corticospinal tracts, cortex, white matter and basal ganglia. * Written informed consent from custodial parent(s). Exclusion Criteria: * Any proven or suspected congenital anomaly, chromosomal disorder, metabolic disorder. * Presence of an infection of the central nervous system. * No realistic prospect of survival, (e.g. severe brain injury), at the discretion of the attending physician.