Efficacy Study of Long-term Parenteral Nutrition With SmofKabiven® E in Lung Cancer Patients Under Anticancer Therapy

Inclusion Criteria: * Metastatic non-small cell lung cancer patient * Adult ≥ 18 years * Starting any 1st, 2nd or 3rd line chemotherapy and/or immunotherapy administered via a central venous catheter (including implanted ports), or receiving the 2nd cycle of aforementioned anticancer treatment * An energy gap of ≥ 40 % and/or 1000 kcal between the target energy intake (30 ± 5 kcal/kg/day) and the actual energy intake at screening, irrespective of weight loss * Functional digestive tract allowing oral intake * If female of childbearing potential, willing to use a sufficiently safe contraception method throughout participation in the study * Signed informed consent from patient or legal representative Exclusion Criteria: * Parenteral nutrition (PN) administered during the preceding month (the sole administration of intravenous glucose is allowed), or standard of care PN planned to start within 3 weeks after baseline visit * More than 1600 kcal/day required as PN * Tube feeding at screening, or planned to start within 3 weeks after baseline visit * Body mass index (BMI) \> 30 kg/m2 * Performance status \> 3 Eastern Cooperative Oncology Group (ECOG) score * Life expectancy \< 3 months * Active bloodstream infection demonstrated by positive blood culture at Screening * Hypersensitivity to fish-, egg, soya- or peanut protein or to any of the active substances or excipients in SmofKabiven E * Severe blood coagulation disorders * Congenital errors of amino acid metabolism * Pathol…