Deferred Versus Fresh Embryo Transfers (NCT03349905) | Clinical Trial Compass
CompletedNot Applicable
Deferred Versus Fresh Embryo Transfers
France237 participantsStarted 2018-09-24
Plain-language summary
Controlled ovarian stimulation (COS) enhances the efficacy of ART (Assisted reproductive technology) by permitting multiple-oocyte yields, but also alters endometrial receptivity (ER) by an advancement of endometrial development which contributes to diminished pregnancy chances. Previous reports suggest that pregnancy rates are increased following deferred frozen embryo transfers. In addition as compared to fresh embryo transfers, frozen embryo transfers seem to be associated with less affected perinatal outcomes, in particular lower risk of preterm birth, small for gestational age and caesarean section. Unfortunately, most of the current evidence is based only on preliminary reports, needing further scientific evidence. Thus, whether differing embryo transfers could restore optimal ER leading to higher live birth rate (LBR) and better obstetrical outcomes as compared to fresh embryo transfers, is actually still under investigation.
Who can participate
Age range18 Years – 40 Years
SexFEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Women \[18 - 40\[years of age (according to date of birth at time of informed consent) who are eligible for ovarian stimulation and ART treatment, including intracytoplasmic sperm injection (ICSI)
* Absence of anatomical abnormalities of the reproductive tract that would interfere with implantation or pregnancy
* Absence of any medical condition in which pregnancy is contraindicated
* Motile, ejaculatory sperm must be available (donated and/or cryopreserved sperm is allowed). Intracytoplasmic sperm injection (ICSI) will be allowed during this trial
* Body mass index 18 to 35 kg/m2, inclusive
* Able to understand the study
* Affiliation with a social security scheme
* Dated and signed inform consent
Exclusion Criteria:
* Altered ovarian reserve (Day3: FSH \>12 UI/l; AMH\<1,0 ng/ml; AFC\<8)
* History or presence of tumours of the hypothalamus or pituitary gland
* Presence of non isolated uni- or bilateral hydrosalpinx
* Abnormal gynaecological bleeding of undetermined origin
* Contraindication to being pregnant and/or carrying a pregnancy to term
* Known infection with human immunodeficiency virus, active hepatitis B or C virus in the female or male partner
* History or presence of ovarian, uterine or mammary cancer
* Known allergy or hypersensitivity to human gonadotropin preparations or to compounds that are structurally similar to any of the other medications administered during the trial
* Substance abuse that would interfere with trial conduct, as …
What they're measuring
1
Live birth rates
Timeframe: ≥ 35 weeks of gestation after the first single blastocyst embryo transfer according to fresh or deferred-frozen transfer.