An Adaptive Study to Match Patients With Solid Tumors to Various Immunotherapy Combinations Based… (NCT03335540) | Clinical Trial Compass
CompletedPhase 1
An Adaptive Study to Match Patients With Solid Tumors to Various Immunotherapy Combinations Based Upon a Broad Biomarker Assessment
United States20 participantsStarted 2018-05-07
Plain-language summary
The purpose of this study is to evaluate the treatment of solid tumors with various immunotherapy combinations. The treatment will be determined based upon a broad biomarker assessment.
Who can participate
Age range18 Years
SexALL
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Inclusion Criteria:
* Participants must have an ECOG performance status of less than or equal to 1
* Participants must have had prior therapy;Participants who have received adjuvant or neoadjuvant anti-PD(L)1 therapy andprogressed within 6 months of completing therapy will be considered IO refractory.
* Participants must have at least 2 lesions with measurable disease as defined by RECIST Version 1.1
Exclusion Criteria:
* Participants with suspected, known, or progressive CNS metastases, have untreated CNS metastases, or have the CNS as the only site of disease
* Participants with carcinomatous meningitis
* Participants with other active malignancy requiring concurrent intervention
Other protocol defined inclusion/exclusion criteria could apply
What they're measuring
1
Number of participants with qualified tumor biopsy specimen at baseline