In recent years evidence has accumulated on the association between age-related decline in multisensory temporal processing and postural control. This proposed project aims at examining GABA-mediated inhibition as the potential mechanism behind this link. Our overarching hypothesis is that changes in the excitatory-inhibitory balance with a reduction of GABAergic inhibition is a common mechanism underlying age-related multisensory and postural deficits potentially mediated by age-related reduction in network segregation. To test this hypothesis, we will assess the relationship between age-related multisensory/postural deficits and age-related reduction in GABA concentration in related brain areas and probe the role of GABA-mediated inhibition using cognitive training that specifically targets inhibitory functions. Our multimodal approach is innovative, and findings from this study has the potential to lead to the development of safe and effective rehabilitation protocols for older adults with impaired multisensory temporal integration and postural control.
Age range
20 Years – 80 Years
Sex
ALL
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Multisensory temporal processing performance change
Timeframe: At the end of 20-day training
Multisensory temporal processing performance change maintenance
Timeframe: 30 days after training
Postural control and gait performance change
Timeframe: At the end of 20-day training
Postural control and gait performance change maintenance
Timeframe: 30 days after training
Brain GABA level change
Timeframe: At the end of 20-day training
Brain GABA level change maintenance
Timeframe: 30 days after training
Resting-state network segregation change
Timeframe: At the end of 20-day training
Resting-state network segregation change maintenance
Timeframe: 30 days after training